The usual dose of Celebrex for osteoarthritis is 200 mg daily or 100 mg twice daily. While patients with rheumatoid arthritis should start with these dosages of Celebrex, some patients with rheumatoid arthritis may benefit from dosage of 200 mg twice daily.

The maximum daily dose of Celebrex should not exceed 200 mg twice daily.

Side effects

Side effects associated with Celebrex can include stomach upset, diarrhea, gas or nausea may occur. If these effects persist or worsen, notify your doctor promptly. Very unlikely side effects, but report promptly if they occur: unusual fatigue, yellowing eyes or skin, severe headache, unexplained weight gain, change in amount of urine.

If you notice any of the following unlikely but very serious side effects, stop taking Celebrex and consult your doctor or pharmacist immediately: black stools, persistent stomach/ abdominal pain, vomit that looks like coffee grounds. In the unlikely event you have an allergic reaction to this drug, seek immediate medical attention. Symptoms of an allergic reaction include rash, itching, swelling, dizziness or trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions

Tell your doctor your medical history, including: allergies (especially allergies to drugs such as sulfas or NSAID like ibuprofen), kidney problems, liver problems, heart disease, alcohol use, high blood pressure, swelling (edema), blood disorders (anemia), serious infections, stomach problems (bleeding or ulcers), asthma, growths in the nose (nasal polyps), dehydration, poorly controlled diabetes. Celebrex may cause stomach bleeding. Daily use of alcohol, especially when combined with Celebrex, may increase your risk for stomach bleeding. Check with your doctor or pharmacist for more information.

Celebrex should be used only when clearly needed during the first 3 months of pregnancy. It is not recommended for use during the last 6 months of pregnancy. Discuss the risks and benefits with your doctor. It is not known whether Celebrex is excreted into breast milk. Due to the potential risk to the infant, breast-feeding while using Celebrex is not recommended. Consult your doctor before breast-feeding.

Caution is advised when Celebrex is used in the elderly, as they may be more sensitive to the side effects of this medication.

Drug Interactions

Tell your doctor of all prescription and nonprescription medications you use, especially of: fluconazole, lithium, "water pills" (diuretics, e.g., furosemide, hydrochlorothiazide), any drugs for high blood pressure, ACE inhibitors (e.g., captopril, lisinopril), corticosteroids (e.g., prednisone), "blood thinners" (e.g., warfarin), NSAID (e.g., ibuprofen, naproxen).

Check all prescription and nonprescription medicine labels carefully since many contain pain relievers/fever reducers (NSAIDs such as ibuprofen, naproxen, or aspirin) which are similar to Celebrex. Aspirin, as prescribed by your doctor for reasons such as heart attack or stroke prevention (usually these dosages are 81-325 mg per day), should be continued.

Celebrex Overdose

If an overdose of Celebrex is suspected, contact your local poison control center or emergency room immediately. Symptoms of an overdose of Celebrex may include severe stomach pain, coffee ground-like vomit, dark stool, ringing in the ears, change in amount of urine, unusually fast or slow heartbeat, muscle weakness, slow or shallow breathing, confusion, severe headache or loss of consciousness.

Notes

Do not share Celebrex with others.

Keep Celebrex out of reach of children.

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