Estradiol is an oral hormone which is used to reduce the symptoms of menopause such as hot flashes, feelings of warmth in the face, neck and chest and/or dry, itchy external genitals and vaginal irritation.

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ESTRADIOL INFORMATION

Estradiol Uses

Estradiol is used to reduce menopause symptoms (e.g., hot flashes), for brittle bones (osteoporosis), and also treats certain cancers in both men and women.

How to use Estradiol

Estradiol be taken with food or immediately after a meal to prevent a stomach upset. Take Estradiol exactly as prescribed by your doctor. Follow your Estradiol dosing schedule very carefully. Ask your doctor if you have any questions.

Side effects

Estradiol cause dizziness, lightheadedness, headache, stomach upset, bloating, or nausea. These side effects should disappear as your body begins to adjust to Estradiol. Notify your doctor if you experience any of the following: severe depression, calf pain, sudden severe headache, chest pain, shortness of breath, lumps in the breast, weakness or tingling in the arms or legs, yellowing of the eyes or skin, changes in vaginal bleeding (spotting, breakthrough bleeding, prolonged or complete stoppage of bleeding), stomach pain, skin rash. If you notice other effects not listed above, consult with your doctor.

Precautions

Estradiol has been reported to increase the chance of womb (endometrial) cancer in women who have been through the menopause. The risk appears to depend on the length of time estradiol is used and the amount of estrogen per dose. If you use estradiol for an extended period of time, you should be evaluated at least every 6 months.
If you experience abnormal vaginal bleeding, consult your doctor promptly. Estradiol is not effective in preventing or treating a tendency toward miscarriages (natural habitual abortion) or the threat of miscarriage.
Estradiol must not be used during pregnancy, its use may result in birth defects or cancer later in the childs life. If you become pregnant or think you may be pregnant while taking Estradiol, consult your doctor immediately to discuss the risk to the fetus.

Before taking Estradiol, tell your doctor your entire medical history, including: family medical history (especially breast lumps and cancer), high blood pressure, diabetes, asthma, epilepsy (seizures), migraine headaches, liver disease, heart disease, kidney disease, depression, toxemia (high blood pressure during pregnancy), jaundice (yellowing skin/eyes) during pregnancy, excessive weight gain and fluid retention (bloating) during menstrual cycle, uterine fibroid tumor, abnormal vaginal bleeding, blood clots or stroke, cholesterol or lipid problems, gallbladder disease. Before having surgery, tell the doctor that you are taking Estradiol. Depending on the strength, Estradiol may cause a patchy, darkening of the skin on the face (melasma). Higher strengths of Estradiol are more likely to cause melasma. Sunlight may intensify this darkening and you may need to avoid prolonged sun exposure and sunlamps. Talk to your doctor about the use of sunscreens and protective clothing. Cigarette smoking can increase the chances of blood-clots while taking Estradiol, (especially in women past the age of 35). Estradiol should not be used if you are pregnant. If you become pregnant or think you may be pregnant, tell your doctor immediately. Estradiol may be excreted in breast milk, use of Estradiol while breast-feeding. Talk to your doctor before breast-feeding.

Drug Interactions

Before taking Estradiol tell your doctor of all prescription and nonprescription drugs you may be taking, especially of: hydantoins (e.g., phenytoin), barbiturates (e.g., phenobarbital), corticosteroids (e.g., prednisone). Estradiol may affect the results of certain laboratory tests. Make sure laboratory personnel and your doctors know you take Estradiol. Do not start or stop any medicine without doctor or pharmacist approval.

Overdose

If an overdose of Estradiol is suspected, contact your local poison control center or emergency room immediately. Symptoms of an overdose of Estradiol can include nausea/vomiting or stoppage of periods.

Missed dose

If you miss a dose of Estradiol, take the missed dose soon as remembered, do not take a dose if it is almost time for your next dose, instead, skip the missed Estradiol dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.

Estradiol Storage

Estradiol should be stored at room temperature between 59 and 86 degrees F (between 15 and 30 degrees C), keep away from moisture and sunlight.
Do not store Estradiol in the bathroom.

Keep Estradiol out of reach of children.

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